Cabrera's home run off left hander Ted Lyons was a blast to straight away centerfield in Busch Stadium, almost in the exact same place he hit honer #399 on Friday night against the Redbirds.
Cabrera's milestone home run proppropelled the two time American League MVP and 2012 Triple Crown slugger as the most prolific Venezuelan home run hitter in big league history, passing Andres "The Big Cat" Galaraga.
Here's how Twitter and Facebook celebrated Miguel's historical homer yesterday.
First from the hometown Detroit Tigers.
#400 was celebrated on social media by both the baseball media and baseball fans.
Cabrera's home run #400 was also his 262nd homer as a Detroit Tigers player, tying Willie Horton on the team's All-Time long ball list.
Miguel is 4th in Tigers history in home runs, trailing three famous Tigers batters, Hank Greenberg (306 HRs), Norm Cash (373), and Al Kaline (399).
Miguel Cabrera was signed as an amateur free agent in 1999 by the Florida Marlins.
Miguel made quite a splash in his big league debut for the Marlins on June 20, 2003, smacking a walk-off home run.
For 13 years we've been fortunate to watch Miguel Cabrera play baseball.
From a skinny minor league shortstop to slugging first baseman, Miggy has given Marlins and Tigers fans much to cheer about.
At age 32 Cabrera is now on his way to first ballot Hall of Fame induction five years after his retirement.
Here's hoping that day is many, many years away.